Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas [RNA-seq]

POLR2A driver-mutation discovery cohort

The original description of recurrent POLR2A mutations as a distinct meningioma driver (Clark et al., Nature Genetics 2016, PMID 27548314), a landmark paper in meningioma genomics. 19 tumors RNA-sequenced representing the major mutation groups (NF2/chr22 loss, POLR2A, KLF4/TRAF7, AKT1/TRAF7), part of the combined GSE85135 SuperSeries, which also includes array data and a companion ChIP-seq SubSeries. A secondary paper (Nat Commun 2023, PMID 37805627) later reused this same RNA-seq data for an unrelated hedgehog-pathway finding, demonstrating this dataset's continued value for secondary analysis.