Expression profiling in grade I and grade II meningiomas and in normal control brain samples

GSE77259Schulten et al., 2016

Overview

Modality: Expression profiling (microarray)
Sample count: 14
Patient count: 14
Institution: Center of Excellence in Genomic Medicine Research, King Abdulaziz University
Corresponding author: Hans-Juergen Schulten
Platform: Affymetrix Human Gene 1.0 ST Array (GPL6244)
Access type: open
Tissue preservation: Not reported
WHO edition: Not reported

Grade breakdown: G1: 10 G2: 4 G3: 0
Sex distribution: 10 female, 4 male (n=14, extracted from GSM 'gender' field)
Age distribution: n=14, range 36-73, mean 54.1 (extracted from GSM 'age' field)
Anatomic location: Per-sample tumor location recorded in GSM characteristics for all 14 samples (e.g. left tentorial, left temporal, occipital, left sphenoid wing, right frontoparietal, cerebellopontine angle, spinal, posterior right subfalcine, right sphenoid wing, right parasagittal, right falcine, right frontal, right temporal); not aggregated into named anatomic categories here, see review note
Brain invasion: 3 of 14 samples (all WHO grade II) explicitly note brain invasion in the per-sample histology characteristic field: Jed18 ('meningothelial with brain invasion'), Jed49 ('atypical with brain invasion'; also a recurrence per its location field 'posterior right subfalcine (recurrence)'), Jed53 ('transitional with brain invasion'). Jed58 ('atypical') does NOT mention brain invasion and is not counted.
Normal/control tissue: commercial reference normal brain RNA (Affymetrix Tissue Map brain reference samples 01-03, http://www.affymetrix.com/support/technical/sample_data/gene_1_0_array_data.affx), not patient-matched and not deposited as individual GSM records (n=3)

WHO grade breakdown availableBrain invasion annotatedPrimary vs. recurrent annotatedPeer-reviewed

Schulten HJ, et al. Microarray Expression Data Identify DCC as a Candidate Gene for Early Meningioma Progression. PLoS One, 2016. PMID 27096627 · DOI
Khan I, et al. Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines. Cancer Cell International, 2017. PMID 28736504 · DOI

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