Meningioma cell reprogramming and microenvironment interactions underlie brain invasion
Brain-invasion-focused spatial transcriptomics
Small (2 tumors) but purpose-built: UCSF/Raleigh Lab specifically dissected and spatially profiled brain-invasive regions of meningioma (PMID 41476144, Neuro-Oncology 2026). This is one of only two records in the entire registry tagged brain_invasion_annotated (the other being gse-183655-scrnaseq, where the tag reflects a sampling-location proxy rather than a formal pathology call), making it a uniquely valuable, if small, resource for anyone studying the invasion phenotype specifically, pending confirmation of the exact per-spot pathology annotation from the paper's methods.
Overview
- Modality
- Spatial transcriptomics
- Sample count
- 2
- Patient count
- Not reported
- Institution
- University of California San Francisco
- Corresponding author
- David Raleigh
- Platform
- 10x Genomics Visium
- Access type
- open
- Tissue preservation
- Not reported
- WHO edition
- Not reported
Cohort detail
- Grade breakdown
- Not reported
- Sex distribution
- Not reported
- Age distribution
- Not reported
- Anatomic location
- Not reported
- Brain invasion
- 2 of 2 tumors specifically selected/dissected for brain-invasive regions
- Normal/control tissue
- None
Interactive gene-expression viewer
Both samples (NP21-104, N21-202), each spot plotted at its true tissue position, side by side · 6,699 cells, 200 genes, 2 samples merged.
Spots are plotted at true tissue position per sample, not merged into one shared coordinate space -- the two samples are independent tissue sections side by side, not directly overlaid.
Loading…
Priority attributes
Publications
- Aggarwal A, et al. Meningioma cell reprogramming and microenvironment interactions underlie brain invasion. Neuro-oncology, 2026. PMID 41476144 · DOI